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Thursday | Friday | Saturday



Wednesday 2 March 2016


18.00 – 20.00


Registration Opens

Thursday 3 March 2016 – Day 1


Special Morning Session: Meet the Professor


08.00 – 08.50


30 years of battling the cell wall
Jean-Paul Latgé, PhD

08.00 – 08.50


Difficult cases of allergic and chronic pulmonary aspergillosis
Eavan Muldoon, MD
Chris Kosmidis, MD PhD


09.00 – 09.10


Conference Introduction
David W. Denning, FMedSci


Session 1: How Aspergillus Turns from Trivial Colonizer into a Pathogen

Moderators: Jean-Paul Latgé, PhD & Dimitros P. Kontoyiannis, MD ScD FACP FIDSA


09.10 – 09.35


How Aspergillus invades the respiratory epithelium
Elaine Bignell, PhD

09.35 – 10.00


Lung mycobiota and aspergillosis
Laurence Delhaes, MD PhD

10.00 – 10.15


Selected Abstract:
Regulation of in vivo fitness and virulence through the Aspergillus fumigatus transcription factor CreA
Sarah Beattie

10.15 – 10.30


Selected Abstract:
A pH-responsive molecular switch required for Aspergillus fumigatus pathogenicity

Margherita Bertuzzi, PhD

10.30 – 10.45


Selected Abstract:
The FxDxF motif in CnaA is essential for proper septal localization and function of calcineurin in Aspergillus fumigatus
Praveen Juvvadi, PhD

10.45 – 11.10


Modelling what happens in the airways
Donald Sheppard, MD


11.10 – 11.40


Coffee Break



Session 2: Airways and Aspergillus Sensitization

Moderators: Elaine Bignell, PhD & Mark R. Nicolls, MD


11.40 – 12.05


Fungal sensitization and allergic aspergillosis in childhood
Richard B. Moss, MD

12.05 – 12.30


Are allergic fungal rhinosinusitis and ABPA lifelong conditions?
Ritesh Agarwal, MD DM

12.30 – 12.45


Selected Abstract:
Relation between gene mutation in cystic fibrosis (CF) and allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS)
Maria Gamaletsou, MD PhD

12.45 – 13.00


Selected Abstract:
The interplay between Aspergillus fumigatus and airway mucins in cystic fibrosis
Abigail Cowley

13.00 – 13.25


Aspergillus and bronchiectasis – are they directly linked?
Anthony de Soyza, PhD MBChB


13.25 – 15.15


Lunch and Poster Session 1


Session 3: Therapy

Moderators: William J. Steinbach, MD & Eavan Muldoon, MBBCh MD MPD


15.15 – 15.40


Challenges of the GRADE classification in developing the IDSA Aspergillus Guidelines
Thomas F. Patterson, MD

15.40 – 16.05


Where expert opinion is unsupported by the evidence – our biggest evidence gaps in European guidelines
Andrew J. Ullman, MD

16.05 – 16.30


Azole concentration and toxicity – is there a relationship?
Li-Ping Zhu, PhD

16.30 – 16.45


Selected Abstract:
In vivo efficacy of intranasally dosed PC945, a novel antifungal agent, in Aspergillus fumigatus infection in immunocompromised mice
Kazuhiro Ito, PhD

16.45 – 17.00


Selected Abstract:
Combination therapy with isavuconazole and micafungin for treatment of experimental invasive pulmonary aspergillosis: preliminary report
Vidmantas Petraitis, MD

17.00 – 17.25


Salvage strategies for IA – how to develop meaningful evidence
Jörg Janne Vehreschild, MD


17.25 – 18.15

Welcome Reception


Session 4: Basilea Satellite Symposium

Moderator: David W. Denning, FMedSci


18.15 – 20.15


Challenges and recent developments in the management of invasive aspergillosis

Invasive aspergillosis – are we making progress in reducing mortality?
Livio Pagano, MD

Pharmacological aspects of the management of invasive aspergillosis

Recent developments in the management of invasive aspergillosis and mucormycosis
Johan Maertens, MD PhD

20.15   Supper


Friday 4 March 2016 – Day 2



Special Morning Session


08.00 – 08.50


Six papers of great interest in 2015-2016
William J. Steinbach, MD
Sean Doyle, PhD

08.50 – 09.00   Resources for researchers
Rory A. Duncan, MS


Session 5: Host Response

Moderators: Robert A. Cramer, PhD & Stuart M. Levitz, MD


09.00 – 09.25


Calcineurin orchestrates macrophage cell death during fungal germination
Darius Armstrong-James, FRCP MSc PhD DipMedMycol

09.25 –09.50


Inborn errors of antifungal immunity
Michail Lionakis, MD ScD

09.50 – 10.05


Selected Abstract:
Innate antifungal effector mechanisms of cystic fibrosis phagocytes
Shan Brunel

10.05 – 10.20


Selected Abstract:
Compartment-specific activation of the inflammasome by Aspergillus fumigatus
Joshua Obar, PhD


10.20 – 10.50


Coffee Break



Session 6: Diagnostics

Moderators: David S. Perlin, PhD & Johan Maertens, MD PhD


10.50 – 11.15


Barcoding, phylogeny, taxonomy and novel methods in biodiversity
Sybren de Hoog, PhD

11.15 – 11.40


Aspergillus antibody testing – have we arrived?
Malcolm Richardson, PhD

11.40 – 11.55


Selected Abstract:
Clinically significant cryptic Aspergillus species in a referral chest hospital Delhi, India: MALDI-TOF identification, sequencing and antifungal susceptibility profiling
Anuradha Chowdhary, MD PhD

11.55 – 12.10


Selected Abstract:
Dectin-2 is a receptor for galactomannan
Jatin M. Vyas, MD

12.10 – 12.25


Selected Abstract:
Selective-fungal culture media associated with high prevalence of Aspergillus in cystic fibrosis
Gina Hong, MD

12.25 – 12.50


Performance evaluation of multiplex PCR including Aspergillus – not so simple!
Stéphane Bretagne, MD PhD


12.50 – 14.45

Lunch and Poster Session 2



Quarry Bank Mill Tour and Concorde Dinner

14.45 – 15.00   Coaches depart Manchester Central Convention Complex for those attending the Quarry Bank Mill Tour AND Concorde Dinner
16.45 – 17.00   Coaches depart Manchester Central Convention Complex for anyone attending the Concorde Dinner ONLY




Saturday 5 March 2016 – Day 3


Special Morning Session: Meet the Professor


08.00 – 08.50


Difficult cases of invasive mycoses
Thomas J. Walsh, MD
Frederic Lamoth, MD

Moderator: David A. Stevens, MD

08.00 – 08.50


Lipid rafts and epigenetics in fungal infection biology
Axel A. Brakhage, PhD



Session 7: Resistance

Moderators: Donald Sheppard, MD & Thomas J. Walsh, MD


09.00 – 09.25


Global azole resistance
Jacques F. Meis, MD PhD

09.25 – 09.40


Selected Abstract:
CYP51-independent isavuconazole-induced resistance in Aspergillus fumigatus
Cristina Jiménez-Ortigosa, PhD

09.40 – 09.55


Selected Abstract:
Autophagy in Aspergillus fumigatus infection and immunity
Vasilis Oikonomou, PhD

09.55 – 10.20


Echinocandin resistance in Aspergillus – does it exist?
David S. Perlin, PhD

10.20 – 10.45


Resistant species
Ana Alastruey-Izquierdo, PhD


10.45 – 11.15

Coffee Break



Session 8: Aspergillus and Disease Establishment

Moderators: Thomas F. Patterson, MD & Karl V. Clemons, PhD


11.15 – 11.40


Global impact of non-human vertebrate cases of aspergillosis
Seyedmojtaba Seyedmousavi, PhD

11.40 – 11.55


Selected Abstract:
Impact of echinocandin exposure on the interactome of Aspergillus fumigatus protein kinase A
Keats Shwab, PhD

11.55 – 12.10


Selected Abstract:
Corticosteroids impair neutrophils but not other CD11b+ myeloid cells to control pulmonary Aspergillus fumigatus infection
Natarajaswamy Kalleda

12.10 – 12.35


Lung transplantation
Mark R. Nicolls, MD

12.35 – 13.00


Orchestrating gene switches during infection by A. fumigatus
Robert A. Cramer, PhD


13.00 – 14.30





Session 9: Genetics

Moderators: Sean Doyle, PhD & Stéphane Bretagne, MD PhD


14.30 – 14.55


CRISPR in A. fumigatus
Sven Krappmann, PhD

14.55 – 15.10


Selected Abstract:
Poly-ICLC confers protection against invasive aspergillosis caused by Aspergillus fumigatus and Aspergillus tanneri
Seyedmojtaba Seyedmousavi, PhD

15.10 – 15.25


Selected Abstract:
The immunoregulatory role of microbiota tryptophan metabolites in fungal allergy
Giuseppe Paolicelli

15.25 – 15.40


Selected Abstract:
Phenotypic maturation of dendritic cells is impaired by the calcineurin inhibitor FK506 in an in vitro model of invasive aspergillosis in lung transplant recipients
Amit Adlakha

15.40 – 16.05


Transcriptional regulation and drug resistance in Aspergillus fumigatus
Michael Bromley, PhD


16.05 – 16.35


Coffee Break



Session 10: Looking into the Future

Moderators: Malcolm Richardson, PhD & Axel A. Brakhage, PhD


16.35 – 17.00


Anti-Aspergillus antifungal pipeline
Dimitrios P. Kontyiannis, MD

17.00 – 17.25


Aspergillus vaccines: Hardly worth studying or worthy of hard study?
Stuart M. Levitz, MD

17.25 – 17.50


Fungal diagnostics – an essential component of the AMR attack plan
David W. Denning, FMedSci

17.50 – 17.55


Closing remarks
David A. Stevens, MD



Snacks, Drinks and Discussion about AAA 2018